مهندسی متالورژی

مهندسی متالورژی

بررسی نقش پلی‌پیرول و پارامترهای الکتروریسی روی خواص داربست پلی‌کاپرولاکتون

نوع مقاله : مقاله پژوهشی

نویسندگان
1 دانشگاه شیراز
2 بخش مهندسی مواد، دانشکده مهندسی دانشگاه شیراز
چکیده
داربست یک بستر موقت برای حمایت از سلول‌ها، با هدف ترمیم و بازسازی عیوب بافت‌های مختلف بدن است و باید ویژگی‌هایی مشابه با بافت هدف داشته باشد. هدف از این تحقیق، ساخت داربست پلی‌کاپرولاکتون و پلی‌کاپرولاکتون/پلی‌پیرول به روش الکتروریسی و بررسی تاثیر غلظت پلی‌کاپرولاکتون (17، 20 و 25 درصد‌وزنی)، ولتاژ (12، 14 و 16 کیلوولت) و غلظت پلی‌پیرول (0، 5/2، 5 و 10 درصد‌وزنی) روی مورفولوژی، ترشوندگی و هدایت الکتریکی الیاف است. نتایج بدست آمده نشان می دهد که افزایش غلظت پلی-کاپرولاکتون، باعث افزایش قطر الیاف، کاهش تعداد مهره‌ها و تغییر مورفولوژی مهره‌ها از حالت کروی به دوکی‌شکل و کشیده شده است. برای همه‌ی نمونه‌ها در ولتاژ 14 کیلوولت، کمترین تعداد مهره مشاهده شد. داربست پلی‌کاپرولاکتون با غلظت 25 درصد‌وزنی و ولتاژ 14 کیلوولت به عنوان نمونه بهینه انتخاب شد و ذرات پلی‌پیرول به این نمونه افزوده شد. با افزودن ذرات پلی‌پیرول با غلظت 5/2 درصد‌وزنی، قطر الیاف افزایش و سپس با افزایش غلظت تا 5 و 10 درصد وزنی، قطر کاهش یافته است و به دلیل ماهیت آب‌دوست پلی-پیرول، افزایش غلظت آن، آب‌دوستی داربست را بهبود بخشیده است. همچنین با افزودن 5 درصد وزنی از ذرات پلی‌پیرول، هدایت الکتریکی الیاف پلی‌کاپرولاکتون از 12-10 × 1/1 به 9-10 × 7/4 زیمنس بر متر افزایش یافته است.
کلیدواژه‌ها

عنوان مقاله English

Investigating the effect of poly-pyrrole and electrospinning parameters on polycaprolactone scaffold properties

نویسندگان English

Seyed Mojtaba Zebarjad 1
Zahra Sabet Bokati 2
1 دانشکده مهندسی بخش مهندسی مواد
2 Department of Materials Engineering, Faculty of Engineering, Shiraz University
چکیده English

The aim of this research is to fabricate polycaprolactone (PCL) and polycaprolactone/poly-pyrrole (PCL/PPy) scaffolds by electrospinning method. In order to investigate the effect of electrospinning parameters and concentration of both polycaprolactone and PPy on the morphology, wettability and electrical conductivity of electrospun scaffold the following method is done. Concentrations of PCL and PPy are selected 17, 20, 25%wt and 0, 2.5, 5 and 10%wt respectively. Also, the electrospinning is performed at different voltage (i. e. 12, 14 and 16 kV). The results indicate that increasing the concentration of polycaprolactone has increased the fiber diameter, decreased the number of beads, and changed the morphology of the beads from spherical to spindle-shaped and elongated. The lowest number of beads is observed for all samples at 14 kV voltage. Polycaprolactone scaffold with a concentration of 25%wt and a voltage of 14 kV is selected as the optimal sample and poly-pyrrole particles were added to this sample. By adding poly-pyrrole particles with a concentration of 2.5%wt, the diameter of the fibers increased, and then by increasing the concentration to 5 and 10%wt, the diameter decreased. Due to the hydrophilic nature of poly-pyrrole, increasing its concentration has improved the hydrophilicity of the scaffold. Also, by adding 5%wt of poly-pyrrole particles, the electrical conductivity of polycaprolactone fibers has increased from 1.1 × 10-12 to 4.7 × 10-9 siemens per meter.

کلیدواژه‌ها English

Polycaprolactone
Poly-pyrrole
Scaffold
Electrospinning
Wettability
Electrical conductivity
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دوره 28، شماره 2
تابستان 1404
صفحه 89-98

  • تاریخ دریافت 16 مرداد 1403
  • تاریخ بازنگری 22 آبان 1403
  • تاریخ پذیرش 13 بهمن 1403