نوع مقاله : مقاله پژوهشی
نویسندگان
1 Pajoohesh
2 مهندسی مواد، گروه مهندسی مواد، دانشگاه بوعلی سینا، همدان، ایران
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Oxide ceramics are mostly bio-inert and need surface modification to increase bioactivity with the bone tissue. This study evaluates the synthesis of hybrid nanofibrous scaffolds of nylon6-hydroxyapatite on toughened alumina-zirconia implants. The Nanostructured-scaffold was created on the surface using electrospinning method. The results showed that the average fiber diameter size was 70-180 nm, the scaffold thickness was less than 500 nm, and open pores with an average size of 500 nm were formed. The thermal stability evaluation showed that the nano-scaffold had thermal stability up to 200 ℃, and the nylon6 polymer matrix practically evaporated at 300 ℃. Bioactivity was evaluated by immersion test in the simulated body fluid (SBF) over 21 days. The results confirmed the formation of a nanostructured bone-like apatite phase with the morphology of blade with a wall thickness of 34 ± 5 nm. The antibacterial activity test showed that the hybrid nanofibrous coating of nylon6-hydroxyapatite on the toughened alumina-zirconia improved the antibacterial activity by 10%. The development of such bioactive coatings paves new ways for the use of bio-inert materials in bone tissue engineering.
کلیدواژهها [English]
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