مهندسی متالورژی

مهندسی متالورژی

بررسی پایداری گرمایی و رفتار زیستی داربست نانوالیاف هیبریدی پلیمر- نانوذرات سرامیک

نوع مقاله : مقاله پژوهشی

نویسندگان
1 Pajoohesh
2 مهندسی مواد، گروه مهندسی مواد، دانشگاه بوعلی سینا، همدان، ایران
چکیده
سرامیک‌های اکسیدی عمدتا رفتار زیست خنثی دارند و نیاز به اصلاح سطح به منظور افزایش زیست فعالیت با بافت استخوان هستند. این پژوهش به بررسی ایجاد داربست نانوالیاف هیبریدی از نایلون۶-هیدروکسی آپاتیت روی کاشتنی آلومینا-زیرکونیای چقرم شده می‌پردازد. نانوداربست به کمک روش الکتروریسی روی سطح ایجاد شد. نتایج نشان داد که میانگین قطر الیاف nm 70-180، ضخامت داربست کمتر از nm 500 و تخلخل‌های باز با میانگین قطر nm 500 ایجاد شدند. ارزیابی پایداری گرمایی نشان داد که نانوداربست تا 200 درجه سانتیگراد پایداری گرمایی دارد و از دمای 300 درجه سانتگیراد عملا زمینه پلیمر نایلون ۶ تخریب می‌شود. زیست فعالی به کمک آزمون غوطه وری در محلول شبیه ساز بدن (SBF) پس از ۲۱ روز بررسی شد. نتایج تشکیل فاز آپاتیت نانوساختار شبه استخوان با ریخت‌شناسی تیغه‌ای شکل با با ضخامت دیواره 5 ± 34 نانومتر را تایید کرد. آزمون فعالیت ضد باکتریایی نشان داد پوشش داربست نانوالیاف هیبریدی از نایلون۶-هیدروکسی آپاتیت روی کاشتنی آلومینا-زیرکونیای باعث بهبود ۱۰ درصد فعالیت ضد باکتریایی می‌شود. توسعه چنین پوشش‌های زیست‌پزشکی زیست فعال راه‌های جدیدی را برای کاربردهای مهندسی بافت استخوان باز می‌کند.
کلیدواژه‌ها

عنوان مقاله English

Study on Thermal Stability and Biocompatibility of Nanofibrous Hybrid Polymer/Ceramic Nanoparticle Scaffolds

نویسندگان English

Hamid Esfahani 1
Mahsa Darvishghanbar 2
1 Pajoohesh
2 Department of mechanical engineering, Engineering faculty, Bu-Ali Sina University, Hamedan, Iran
چکیده English

Oxide ceramics are mostly bio-inert and need surface modification to increase bioactivity with the bone tissue. This study evaluates the synthesis of hybrid nanofibrous scaffolds of nylon6-hydroxyapatite on toughened alumina-zirconia implants. The Nanostructured-scaffold was created on the surface using electrospinning method. The results showed that the average fiber diameter size was 70-180 nm, the scaffold thickness was less than 500 nm, and open pores with an average size of 500 nm were formed. The thermal stability evaluation showed that the nano-scaffold had thermal stability up to 200 ℃, and the nylon6 polymer matrix practically evaporated at 300 ℃. Bioactivity was evaluated by immersion test in the simulated body fluid (SBF) over 21 days. The results confirmed the formation of a nanostructured bone-like apatite phase with the morphology of blade with a wall thickness of 34 ± 5 nm. The antibacterial activity test showed that the hybrid nanofibrous coating of nylon6-hydroxyapatite on the toughened alumina-zirconia improved the antibacterial activity by 10%. The development of such bioactive coatings paves new ways for the use of bio-inert materials in bone tissue engineering.

کلیدواژه‌ها English

Bone like apatite
Bioactive
Ceramic implants
Electrospinning
Nano-fiber
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  • تاریخ دریافت 06 تیر 1402
  • تاریخ بازنگری 08 اسفند 1402
  • تاریخ پذیرش 09 اسفند 1402