ساخت و بررسی سمیت نانو ذرات CuFe2O4 سنتز شده به روش سل ژل احتراقی برای کاربرد هایپرترمیا

نوع مقاله : مقاله پژوهشی

نویسندگان

1 کارشناسی ارشد، مرکز تحقیقات مواد پیشرفته، دانشکده مهندسی مواد، واحد نجف آباد، دانشگاه آزاد اسلامی، نجف آباد، ایران.

2 دانشیار، مرکز تحقیقات مواد پیشرفته، دانشکده مهندسی مواد، واحد نجف آباد، دانشگاه آزاد اسلامی، نجف آباد، ایران.

3 استادیار، مرکز تحقیقات مواد پیشرفته، دانشکده مهندسی مواد، واحد نجف آباد، دانشگاه آزاد اسلامی، نجف آباد، ایران.

چکیده

نانو ذرات مغناطیسی به دلیل منحصر به فرد بودن خواص شیمیایی و فیزیکی و استفاده از آن ها در کاربردهای پزشکی از جمله هایپرترمیا، توجه زیادی را به خود جلب کرده است. در این پژوهش نانو ذرات فریت مس توسط روش سل ژل احتراقی سنتز گردید. محصول بدست آمده توسط پراش اشعه ایکس (XRD)، طیف سنجی تبدیل فوریه مادون قرمز (FTIR)، آزمون جذب و واجذب نیتروژن (BET)، میکروسکوپ الکترونی روبشی (FESEM)، آنالیز عنصری نقطه­ای، و آزمون مغناطیس سنجی نمونه ارتعاشی (VSM) مورد مطالعه قرار گرفت. متوسط اندازه بلورک در حدودnm  8 ± 25 و مساحت سطحی ویژه آن حدودg/m2   20/0 ± 59/2بدست آمد. مورفولوژی و شکل نانو ذرات به صورت کروی و متوسط اندازه نانو ذرات فریت مس حدوداً nm 10 ± 96 اندازه گیری شد. فریت مس دارای خاصیت فری مغناطیس است و مغناطیس اشباع حدود emu/g 28/29 اندازه گیری شد. رهایش داروی ایبوپروفن از این نانوذرات مورد بررسی قرار گرفت. سازگاری سلولی و بحث سمیت سلولی نانو ذرات تولیدی بر روی سلول سرطانی HT29 مورد ارزیابی قرار گرفت.نانو ذرات فریت مس CuFe2O4، توسط روش هایپر ترمیا نیز مورد تجزیه و تحلیل قرار گرفت و افزایش دما تا حدود 42 درجه سانتیگراد و نرخ جذب ویژه ((W/g 62/ 9 بدست آمد.

کلیدواژه‌ها

عنوان مقاله [English]

Fabrication and Investigation of Toxicity of CuFe2O4 Nanoparticles Synthesized by Combustion Sol-Gel Method for Hyperthermia Application

نویسندگان [English]

  • Mahdi Talaei 1
  • Seyed Ali Hassanzadeh Tabrizi 2
  • Ali Saffar Teluri 3
1 M.Sc, Advanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran.
2 Associate Professor, Advanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran.
3 Assistant Professor, Advanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran.
چکیده [English]

Magnetic nanoparticles have attracted a lot of attention due to their unique chemical and physical properties and their use in medical applications such as hyperthermia. In this research, copper ferrite nanoparticles were synthesized by combustion gel-sol method. The synthesized samples were studied by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, nitrogen adsorption and desorption test (BET), energy dispersive spectroscopy (EDS), scanning electron microscopy (FESEM) and vibrational sample magnetometry (VSM). The average crystal size was about 25 ± 8 nm and its specific surface area was about 2.59±0.20 m2/g. Morphology and shape of nanoparticles were spherical and the average size of copper ferrite nanoparticles was about 96 ± 10 nm. Copper ferrite has ferromagnetic properties and saturation magnet was obtained at about 29.28 emu/g. the release of ibuprofen from these nanoparticles was investigated. Cytotoxicity of the nanoparticles on HT29 cancer cells was evaluated. CuFe2O4 copper ferrite nanoparticles were also analyzed by hypothermia method. The results showed a rise in temperature to about 42 ° C and a specific adsorption rate of 9.62 W/g.

کلیدواژه‌ها [English]

  • Magnetic nanoparticles
  • Copper ferrite
  • Sol-gel
  • Cytotoxicity
  • Hyperthermia

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سابقه مقاله

  • تاریخ دریافت: 31 شهریور 1399
  • تاریخ بازنگری: 14 بهمن 1399
  • تاریخ پذیرش: 26 بهمن 1399

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